Sequential Clomiphene Citrate and FSH compared to Clomiphene Citrate and hMGon Pregnancy Rate in Intrauterine Insemination Cycles.
- Author:
Goo Sung JUNG
;
Ki Eon HONG
;
Seung Hwan YOU
;
Hyeon Sook LEE
;
Jong In LEE
;
Young Mun HUR
;
Eun Suk JEON
;
Jeong Im YOON
;
Jeong Eui HONG
;
Ji Sam LEE
- Publication Type:Original Article
- MeSH:
Clomiphene*;
Estradiol;
Female;
Gestational Sac;
Gonadotropins;
Humans;
Infertility;
Insemination*;
Ovulation;
Pregnancy Rate*;
Pregnancy*;
Sperm Count;
Ultrasonography
- From:Korean Journal of Fertility and Sterility
1999;26(3):433-440
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the effectiveness of CC+FSH or CC+hMG in intrauterine insemination (IUI) cycles for the treatment of infertility. METHOD: Patients received daily 100 mg of clomiphene citrate (CC) for 5 days followed by hMG or FSH. A single IUI was performed at 36 h after hCG. Clinical pregnancy was classified if a gestational sac or fetal cardiac activity was seen on ultrasound. RESULTS: The overall clinical pregnancy rate was 19.1% per cycle (17/89) and 21.5% per patient (17/79). More clinical pregnancies were recorded in CC+FSH (23.1%, 6/26) than CC+hMG cycles (17.5%, 11/63), but this difference was not statistically significant. No differences were found in age, duration of infertility, follicle size, levels of estradiol (E2) on the day of hCG injection and total motile sperm counts between pregnant and non-pregnant groups. However, more ampules of gonadotropins were used in pregnant group than non-pregnant group (p<0.05). CONCLUSION: Combination of CC and hMG may economically be more effective to induce ovulation for IUI compared to CC and FSH.
