The effect of mild hypothermia on inflammation after cerebral ischemia-reperfusion in rats
- VernacularTitle:亚低温对大鼠缺血-再灌流后脑梗死体积、神经功能及炎症反应的影响
- Author:
Xinguo YE
;
Shaozu YU
;
Chengyan LI
- Publication Type:Journal Article
- Keywords:
Mild hypothermia;
Neuroprotection;
Ischemia-reperfusion injury;
Inflammation
- From:
Chinese Journal of Emergency Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective effect of mild hypothermia against inflammatory cascade reaction in rats during cerebral ischemia and reperfusion.Methods After middle cerebral artery occlusion(MCAO)for 3 h in rats,the expression levels of ICAM-1,TNF-? and IL-1 ? in the ischemic regions were determined at different reperfusion time (6 h,12 h,24 h,48 h and 72 h).At 24 h,the cerebral infarction volume and neurologic function were evaluated.In the control,these were assessed at 24 hours reperfusion.Results (1)Mild hypothermia could ameliorate neurological deficit score and decrease infarct volume induced by cerebral ischemia and reperfusion.(2)The expression of ICAM-1,TNF-? and IL-1? rose obviously at 6 h after cerebral ischemia-reperfusion,and peaked each at 48 h,24 h and 6 h.There was significant difference between the various groups and the sham-operative group(P
