EFFECTS OF COMBINED NEURAL STEM CELLS AND BDNF ON NOS-POSITIVE NEURONS OF BASAL FOREBRAIN OF AD RAT
- VernacularTitle:神经干细胞与脑源性神经营养因子联合治疗对老年性痴呆鼠基底前脑一氧化氮合酶阳性神经元的影响
- Author:
Dandi YANG
;
Dahong LONG
- Publication Type:Journal Article
- Keywords:
Neural stem cells;
Brain-derived neurotrophic factor;
NOS-positive neuron;
Alzheimer disease;
transplantation;
Call culture;
Rat
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of combined neural stem cells(NSCs) and brain-derived neurotrophic factor(BDNF) on NOS-positive neurons of basal forebrain of rats with Alzheimer disease(AD). Methods Adult SD rats with left fimbria-fornix(FF) transection received neural stem cells transplanted in the basal forebrain.Then BDNF was continuous injected into lateral ventricle.After 4 weeks,morphologic data and percentages of NOS-positive neurons were measured in basal forebrain by using histochemical method combined with technique of micromeasure and image analysis. Results About 1 month after FF lesion,35.5% and 55.8% of NOS-positive neurons were survived in medial septum(MS) and vertical diagonal band(VDB) of the lesion side of basal forebrain,(P
