THE STUDY ON THE DISTRIBUTION OF DENDRITIC CELLS AND EXPRESSIONS OF E-CADHERIN AND ICAM-1 IN MUSCOSAL IMMUNE MOUSE MODEL
- VernacularTitle:树突状细胞在黏膜免疫模型小鼠中的分布及E-cadherin和ICAM-1表达的研究
- Author:
Chuanlong FANG
;
Zunjiang XIE
- Publication Type:Journal Article
- Keywords:
Dendritic cells;
E-cadherin;
ICAM-1;
Immunohistochemistry;
Muscosal immune mouse model
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distributive characteristics of DC and the expressions of E-cadherin and ICAM-1 in muscosal immune mouse model,to discuss the regulative role for E-cadherin and ICAM-1 in the DC migration. Methods By the method of immunohistochemistry staining and light microscopy,we observed the distributive characteristics of DC in muscosal immune mouse model,analysed the expressions of E-cadherin and ICAM-1. Results The DC mainly distributed in mesenteric lymph node(MLN),Peyer's patch(PP),and GUT(stomach,jejunum and ileum) of muscosal immune mouse model.The number of DC was larger in the experiment group than that in control group.The expression of ICAM-1 was higher,but lower of E-cadherin in muscosal immune mouse model.The number and area density of experiment group were greater compared with that of control group.Conclusion The E-cadherin and ICAM-1 may play a critical role in DC migration.
