Effect of Guyanding Decoction on the Metabolism of Oxygen-derived Free Radicals in Chicken Knee Osteoarthritis
- VernacularTitle:骨炎定对鸡膝关节骨性关节炎氧自由基代谢的影响
- Author:
Yanming CAO
;
Haibo XU
;
Jichang CHENG
- Publication Type:Journal Article
- Keywords:
Decoction of GYD;
Osteoarthritis;
Oxygen-derived free radicals;
MDA;
SOD
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Obstract: Objective To study the effect of Guyanding Decoction(GYD) on the metabolism of oxygen-derived free radicals in the chicken model of knee osteoarthritis and to explore its therapeutic mechanism.Method Forty chickens were randomized into 5 groups: normal group,model group,low-dose GYD group,high-dose GYD group and Fenbid group.Low-dose group was administered 5 g/kg GYD and high-dose group with 10 g/kg GYD by gastric gavage.Fenbid group was given Fenbid 0.15 g/kg.The SOD activity and the MAD content in serum were detected in each group.Result The activity of SOD in model group was significantly lower than that in normal group(P 0.05).For the content of MDA,model group had a higher level than normal group(P 0.05).Conclusion The decoction of GYD exerts curative effect on experimental osteoarthritis by improving the activity of SOD,eliminating excessive oxygen-derived free radicals,decreasing the content of MDA,and preventing osteoarthritis patients from the injury of oxygen-derived free radicals.
