Antitumor Activity of Wei Yi Ting Granules on S_(180) Sarcoma Mice and Its Influence on the Expression of P~(53) and PCNA
- VernacularTitle:胃移停颗粒对S_(180)小鼠抑瘤作用及其对P~(53)和PCNA表达的影响
- Author:
Zhongdong YIN
;
Yu CAI
- Publication Type:Journal Article
- Keywords:
Wei Yi Ting granule;
P53;
PCNA;
Expression of gene
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the antitumor action of Wei Yi Ting granules (WYTG) and to explore its possible mechanism.Methods The inhibitory effect of WYTG and its different WYTG ingredient combinations on the growth of S180 tumor in mice was observed.Meanwhile,the effect of WYTG and its different ingredient combinations on the expression of P53 and PCAN during tumor development was studied by immunohistochemical method.Results WYTG had an obvious inhibitory effect on tumor growth and could reduce the positive cell number of P53 and PCAN,the difference being significant as compared with the blank control group(P 0.05).Conclusion WYTG,which has the actions of strengthening Qi,activating blood and removing toxicity,exerts an obvious inhibitory effect on tumor as compared with its ingredient combination of strengthening Qi and with that of strengthening Qi and removing toxicity.Its therapeutic mechanism may be related to the inhibition of the expression of P53 and PCAN and the influence on tumor-associated gene during the growth of tumor.
