Optimization of breviscapin sustainded release tablets by mixture uniform design
- VernacularTitle:混料均匀设计法在灯盏花素骨架片处方配比中的应用研究
- Author:
Qingfei LIU
;
Guoan LUO
;
Yiming WANG
- Publication Type:Journal Article
- Keywords:
mixture uniform design;
breviscapin;
sustained release tablets
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To optimize the excipient formulation of lactose,HPMC_(SH4000) and Carbopol 71 G in breviscapin sustained release tablets by mixture uniform design. METHODS: Different formulations,single factor f_2 and multifactors of cumulative release as index,were evaluated respectively. RESULTS: The optical formulations obtained by the two methods were identical,and the tablets with optical formulation had ideal sustained release. CONCLUSION: Mixture uniform design is simple,direct and uniform.It can be used in optimization of formulation with invariable amount.
