Study of the role of glucocorticoid receptor ? in the pathogenesis of systemic lupus erythematosus
- VernacularTitle:糖皮质激素受体?在系统性红斑狼疮发病机制中的作用研究
- Author:
Xiu LI
;
Fengshan ZHANG
;
Yingnan LI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Receptors, glucocorticoid;
Pathogenesis
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of GR? mRNA in the peripheral blood mononuclear cells (PBMCs) of SLE patients and analyze the relationship between GR? and immune parameters, SLEDAI score, in order to reveal the role of GR? in the pathogenesis of SLE. Methods Applying reverse transcription-polymerase chain reaction(RT-PCR) technique to semiquantitatively analyze GR? mRNA expression in SLE patients and healthy volunteer individuals. The relationship between GR? and ANA, anti-ds-DNA antibodies, SLEDAI score was analyzed. Results The expression of GR? mRNA in SLE was significantly lower than that of control group (P
