Comparison of pharmacokinetics between puerarin and its phospholipid complex in Beagle dogs in vivo
- VernacularTitle:葛根素及其磷脂复合物在Beagle犬体内的药动学比较
- Author:
Ying LI
- Publication Type:Journal Article
- Keywords:
puerarin;
phospholipid complex;
Beagle dogs;
in vivo pharmacokinetics
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of puerarin and its phospholipid complex in Beagle dogs in vivo.Methods To determine the puerarin concentration in blood by HPLC,carry on the cross-experiments in the same group of dogs,and calculate the data using 3P97 pharmacokinetic program software.Results The concentration-time profiles of puerarin after ig puerarin and its phospholipid complex(equivalent to 52.5 mg/kg of puerarin) were shown to fit two-compartment open model with first-order absorption.Their AUC,C_(max),and t_(max) for puerarin were(10.91?4.83) mg?h/L,(3.00?1.13) mg/L,and(1.62?0.30) h,while for puerarin in phospholipid complex were(13.67?2.72) mg?h/L,(1.91?0.51) mg/L,and(2.38?1.27) h,respectively.Difference in AUC is significant.Conclusion(Phospholipid complex) formation can effectively enhance puerarin absorption in Beagle dogs in vivo.
