Effects of vitamins A, E, and C with total parenteral nutrition (TPN) on antioxidation in peritoneal sepsis
- VernacularTitle:腹腔感染后维生素A、E、C代谢障碍的防治
- Author:
Yang BAO
;
Weiqin LI
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Vitamins;
Sepsis;
Antioxidation
- From:
Chinese Journal of Emergency Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of vitamins A, E, and C with TPN on antioxidation in peritoneal sepsis. Methods The rat model of intraperitoneal infection was established by cecal ligation and puncture (CLP). Health male SD rats were divided into control group (CLP+TPN), treatment group (CLP + TPN + Vitamin A, E, C), and delayed-treatment group ( CLP + TPN + delayed use of Vitamin A, E, C). Levels of the vitamins, MDA, and GSH in plasma and liver were measured. Results Vitamins A, E, C and GSH in the control group were lower than those in the normal control, and MDA was higher. Vitamins A, E, C and GSH in plasma and the liver in the treatment group and delayed-treatment group were higher than those in the control group, but delayed-treatment group was lower than treatment group. MDA in the treatment group and delayed-treatment group was lower than that in control group, but delayed-treatment group was higher than treatment group. Conclusion Vitamins A, E, C with TPN may effectively ameliorate the oxidative injuries in peritoneal sepsis.
