The effects of ammonium perchlorate (AP) on pulmonary fibrosis
- VernacularTitle:过氯酸铵致肺纤维化作用的研究
- Author:
Mingfen SONG
;
Kailiang PENG
;
Chong WANG
;
Yun LIU
;
Cuirong LU
- Publication Type:Journal Article
- Keywords:
Ammonium perchlorate;
Pulmonary iibrosis;
Transforming growth factor ?1;
Fibroblasts
- From:
Chinese Journal of Emergency Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of AP on pulmonary fibrosis. Methods Alveolar macrophages (AM) were treated by AP for 24 hours. Pulmonary fibroblasts (FB) were cultured with the supernatant of AM medium. The protein of transforming growth factor beta 1 (TGF-?1) of AM, the proliferative activity and hydroxyproline (Hyp) content of FB were examined. Rats were treated with AP by intratracheal instillation and sacrificed at 3 days. The TGF-?1 mRNA content in the lung was examined. Results The positive staining macrophages in low and high AP groups and the quantity of TGF-?1 in high AP group were obviously higher than those in the control group (P
