Effect of probucol on pancreatic ?-cells in STZ-induced diabetes mice
- VernacularTitle:抗氧化剂丙丁酚对STZ导致的糖尿病小鼠胰岛?细胞功能的影响
- Author:
Xiulan YE
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Probucol;
Beta cells;
Streptozotocin
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of probucol on pancreatic ?-cells in STZ-induced diabetes mice.Methods: The mice were randomly divided into four groups with ten mice in each group.The first group was given standard food(C group),The second group given standard food and 1% probucol(C+T group).The third group given standard food and treated with multiple low-dose of STZ(D group),and the forth group given standard food,1% probucol as well as treated with multiple low-dose of STZ(D+T group).The preventive intervention was undertaken with standard diet mixed with 1% probucol in Kunming mice.At different time after STZ was injected intraperitoneally,fasting blood glucose was measured.Serum insulin and glucose tolerance test was done.The pancreatic pathological changes were investigated under light microscope.Results: The fasting blood glucose at 0,1,2,3 weeks in D+C group was lower than that in D group(P
