Effects of short-term rosiglitazone on abdominal fat distribution in patients with type 2 diabetes
- VernacularTitle:短期罗格列酮钠治疗对2型糖尿病腹部脂肪分布的影响
- Author:
Rong LUO
- Publication Type:Journal Article
- Keywords:
Rosiglitazone;
Fat distribution;
Type 2 diabetes
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the effects of short-term treatment of sodium rosiglitazone or rosiglitazone maleate on abdominal fat distribution in patients with type 2 diabetes.Methods: 36 patients with type 2 diabetes who were inadequately controlled by sulfonylureas were randomized into two groups,Group A and Group B,treated with sodium rosiglitazone and rosiglitazone maleate respectively for 12 weeks.Subcutaneous and visceral fat areas at L4 level were measured at baseline and endpoint by CT scanning.Results: At endpoint,the levels of fasting plasma glucose(FPG),two-hour postprandial plasma glucose(PPG),HbA1c,fasting insulin and HOMA-IR decreased significantly in both Group A and Group B(P0.05).Conclusion: Treatment with short-term rosiglitazone in patients with type 2 diabetes leads to fat redistribution from visceral fat to subcutaneous fat.
