Therapeutic potential of madecassoside in transgenic mice of amyotrophic lateral sclerosis
- VernacularTitle:羟基积雪草苷对转基因肌萎缩侧索硬化小鼠的治疗作用
- Author:
Yingju LIU
- Publication Type:Journal Article
- Keywords:
madecassoside;
amyotrophic lateral sclerosis(ALS);
Cu,Zn superoxide dismutase(SOD1)
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic potential of madecassoside in mice expressing a mutant human Cu,Zn superoxide dismutase(SOD1)-G93A linked to human amyotrophic lateral sclerosis(ALS).Methods Effects of madecassoside on onset of clinical disease,survival of mice,decline of motor function,and motor neuron(MN) degeneration were observed by behavioral analysis and histological eva-(luation.) Results Madecassoside(61.1?11.0) and(185.6?18.7) mg/(kg?d) ig administration,beginning at 70 d of age until death,prolonged survival of SOD1-G93A ALS mice by 11.4 and 9.4 d,respectively(P
