Preventive and Therapeutic Effect of Modified Jinsuo Gujin Pill on Adriamycin-induced Nephropathy in Rats
- VernacularTitle:金锁固精丸加味方对大鼠阿霉素肾病的防治作用
- Author:
Qiulin ZHANG
;
Qinguo HONG
- Publication Type:Journal Article
- Keywords:
JINSUO GUJIN PILL/pharmacology;
NEPHROTIC SYNDROME/TCD therapy;
NEPHROTIC SYNDROME/pathology;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the therapeutic effect of Modified Jinsuo Gujin Pill (MJGP) on adriamycin-induced nephropathy in rats. [Methods] Twenty-four SD rats were randomized into normal control group, model group and MJGP group. Except the normal control group, rats in the other two groups were injected with one-dose adriamycin (6 mg/kg) into the caudal vein to induce nephrotic syndrome. Meanwhile, MJGP group was given MJGP decoction 96g/kg and the normal control group was given water of the same volume for 45 days. The effects of MJGP on the levels of 24-hour urine protein, serum total protein (TP), albumin (ALB), serum total cholesterol (TC), blood urea nitrogen (BUN) and serum creatinine (SCr), as well as on the renal histological features were observed. [Results] MJGP decreased the levels of 24-hour urine protein and serum TC, and increased serum TP and ALB levels, the difference being significant as compared with the model group (P
