Electrical stimulation of cerebellum′s fastigial nucleus protects neurogenic autonomic function in rats after ischemic stroke
- VernacularTitle:电刺激小脑顶核对脑源性自主神经活性的保护作用
- Author:
Yiming WANG
;
Xingde LIU
;
Weiwei DONG
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Heart rate variability;
Cerebellar fastigial nucleus stimulation;
Fastigial nucleus lesions
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of electrical stimulation of the cerebellum′s fastigial nucleus on neurogenic autonomic functional disturbances in rats after ischemic stroke. Methods Right middle cerebral artery occlusions (MCAOs) were performed on rats and their heart rate variability (HRV) was analysed. The MCAO rats were randomly divided into a group whose cerebellar fastigial nuclei (FNS) were stimulated and a control group. The power spectrum components and chaos of their heart rate variability were analysed. The MCAOs were performed after two cerebellar fastigial nuclei had been destroyed by pretreatment with ibotenic acid (IBO), to investigate the effect of stimulating the cerebellum′s fastigial nucleus on heart rate variability. Results The power spectral components and chaos in the heart rate variability of the MCAO rats were reduced, and there was a significant difference in the effectiveness rate compared with the sham groups (P
