The effect of electroacupuncture on dopaminergic neurons
- VernacularTitle:电针治疗对帕金森病大鼠多巴胺能神经元的影响
- Author:
Jun MA
;
Yanchun WANG
;
Shuiyong GAN
- Publication Type:Journal Article
- Keywords:
Electroacupuncture;
Substantia nigra;
Parkinson′s disease
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of electroacupuncture (EA) on dopaminergic neurons in the mesencephalic substantia nigra(MSN) of rats with Parkinson′s disease (PD). Methods A model of PD was induced in rats by injecting 6-hydroxydopamine (6-OHDA) into the MSN. Acupuncture was then used to treat the model rats. To examine the apoptosis of dopaminergic neurons, the number of tyrosine hydroxylase (TH) positive neurons and the concentration of dopamine (DA) were measured in a normal control group、a sham-operation group、the EA group and the PD group which received no EA. Results In the EA group, markedly less apoptosis of dopaminergic neurons was observed, and the number of TH positive neurons and the concentration of DA were significantly higher. Conclusion Electroacupuncture may mitigate injury to the substantial nigra in Parkinson′s disease.
