Concentrations of sICAM-1 and sE-selectin in sera from patients with autoimmune rheumatic disease
- VernacularTitle:可溶性细胞间黏附分子-1和可溶性选择素E在自身免疫性风湿病中的表达
- Author:
Bo JIANG
;
Hong WU
;
Shifeng CHEN
;
Longjing WU
- Publication Type:Journal Article
- Keywords:
Cell adhesion molecules;
E-selectin;
Lupus erythematosus, systemic;
Arthritis, rheumatoid;
Dermatomyositis
- From:
Chinese Journal of Rheumatology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the sera level of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) in patients with rheumatic diseases and to explore the correlation between the sera level of soluble adhesion molecules (sAM) and clinical findings. Methods The concentrations of sICAM-1 and sE-selectin in the sera of patients with rheumatic diseases (SLE, RA, PM/DM) and patients without rheumatic diseases, as well as the healthy controls were measured by the enzyme-linked immunosorbent assay (ELISA). After that, the correlation of the concentrations of sAM and clinical data as well as other laboratory parameters (RF, CK, anti-dsDNA) were analyzed. Results The concentrations of sICAM-1 and sE-selectin in all three group patients were significantly higher than those of non-autoimmune rheumatic diseases and healthy controls (P
