A Study in Effect of Artemisinin and its Derivatives on Reversion of Multi-drug Resistance of Tumors
- VernacularTitle:青蒿素及其衍生物逆转肿瘤耐药作用初探
- Author:
Cuiyan LU
;
Xinyi CHEN
;
Binghua TANG
- Publication Type:Journal Article
- Keywords:
artemisinin;
dihydroartemisinin;
artemisunate;
multi-drug resistance
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Effect of artemisinin and its derivatives on multi-drug resistance of tumor cells. Method The inhibition of cell proliferation and RI (reversal index) were determined by MTT method. Results The inhibitory effect of dihydroartemisinin and artemisunate on the proliferation of tumor cell is stronger than that of artemisinin. Artemisinin could partly improve KBv200 cell sensitivity to VCR in different concentrations. Conclusion Artemisunate and dihydroartemisinin effectively inhibited the proliferation of KBv200. Artemisinin could partly improve KBv200 cells sensitivity to chemotherapy medicine.
