The Influence of Invigorating Spleen and Restoring Virility to the Nerve Peptide Y Level In Brain and Gene Expression
- VernacularTitle:健脾与补肾对脑内神经肽Y水平和基因表达的影响
- Author:
Huinan QIAN
;
Haixia WU
;
Le WANG
- Publication Type:Journal Article
- Keywords:
Invigorating spleen and restoring virility;
NPY;
Gene expression
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Comparison on the influence of invigorating spleen and restoring virility to the NPY level in brain and gene expression. Method Establishing the spleen insufficiency model of rat by adopting bitter decline diarrhea, wild eating and overworking, to examine the hypothalamus ventral kernel, the hippocampi CA1 area and forehead cortex, the gene expression change of NPY. Result In the model group, the immunoreaction masculine substance of NPY, hypothalamus ventral kernel,hippocampi CA1 area and prefrontal cortex decreases obviously. The immunoreaction masculine substance of NPY on above mentioned parts in the group of invigorating spleen and restoring virility increases distinctly. In the model group, the expression of NPY mRNA on prefronta cortex and hypothalamus ventral kernel decreases obviously, while on the groups of invigorating spleen and restoring virility increases obviously. Conclusion In the model group, the NPY level and gene expression in brain to promote study memory changed. Invigorating spleen and restoring virility may affect study memory by regulating the NPY level and gene expression.
