Self-microemulsifying drug delivery system of Acanthopanax senticosus total saponin
- VernacularTitle:刺五加总苷自微乳制备工艺的研究
- Author:
Haiyan ZHAO
;
Jianping LIU
;
Rongrong TANG
;
Bo PAN
- Publication Type:Journal Article
- Keywords:
Acanthopanax senticosus total saponins(ASTS);
self-microemulsifying drug delivery system(SMEDDS);
pseudo-ternary phase diagram;
isofraxidin;
HPLC
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop self-microemulsifying drug delivery system(SMEDDS) of Acanthopanax senticosus total saponins(ASTS) and the determination method.Methods The equilibrium solubility of ASTS in different compositions of oils,emulsifier and assistant emulsifier was investigated.The self-microemulsion formula was optimized by constructing the pseudo-ternary phase diagrams of blank SMEDDS and the studying the self-microemulsifying efficiency and the stability of drug-loaded SMEDDS.Taking isofraxidin,an effective component of A.senticosus,as the content determination index,the content was determined by HPLC.Results The optimal self-microemulsion formula was composed of Caf,propanediol,and ethyl linolenate.The ratio of them was 16∶4∶5.The average particle size was 40 nm.The average content of isofraxidin was 92.6 ?g/mL.Conclusion The acquired microemulsion with small particle size is stable.The content determination method of taking isofraxidin as the quality control index is accurate and reliable.
