Hand, Foot, and Mouth Disease: Clinical and Virological Investigations.
- Author:
Young Jin OH
;
Baik Kee CHO
;
Jung Won KIM
;
Won HOUH
;
Yeun Tai LEE
- Publication Type:Original Article
- MeSH:
Fever;
Foot*;
Gingiva;
Hand*;
Hand, Foot and Mouth Disease;
HeLa Cells;
Humans;
Mouth Diseases*;
Mouth Mucosa;
Mouth*;
Palate, Soft;
Tongue;
Virion
- From:Korean Journal of Dermatology
1980;18(5):409-416
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hand, foot and mouth disease, a distinctive clinical syndrome caused by a coxsackie virus, is clinically characterized by vesicles appearing on the hands, feet and in the mouth. The infection begins with a fever and mouth lesions consisting of small vesicles surrounded by red areolae on the buccal mucosa, tongue, soft palate and gingiva. The disease usually lasts spontaneously between 7 to 10 days after onset. We observed 20 cases of hand, foot, and mouth disease from July, 12th to September, 4th, 1979 and examined histopathologically and virologically. We have isolated only one viral strain showing cytopathic effect on HeLa cell among the five cases of acute stage and also observed that viral particle in the electronmicroscope.
