ULTRASTRUCTURAL CHANGES OF CEREBRAL TISSUE IN THE LATERAL RECESS OF THE FOURTH VENTRICLE IN BALB/c MICE AFTER SINGLE ORAL ADMINISTRATION OF STERIGMATOCYSTIN
- VernacularTitle:杂色曲霉素单次灌胃后小鼠第四脑室外侧隐窝超微结构的变化
- Author:
Qingmao HAO
;
Xianghong ZHANG
- Publication Type:Journal Article
- Keywords:
Lateral recess;
Ependymal cell;
Neuron;
Endothelial cell;
Sterigmatocystin;
Electron microscopy;
Mouse
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of sterigmatocystin(ST) on the ependymal cells,neurons and endothelial cells of blood vessel of the lateral recess of the fourth ventricle in BALB/c mice in vivo after single oral administration. Methods BALB/c mice were treated intragastrically by gavage with ST 3000??m/kg.The mice were killed 1 hour,2 hours,4 hours,8 hours,16 hours after oral administration respectively for observing ependymal cells,neurons and endothelial cells of blood vessel of the lateral recess with transmission electron microscopy(TEM).Results After oral administration of ST pinocytosis vesicles began to increase in endothelial cells of blood vessel in 1 hour,apocrine of ependymal cells began to increase and myelin sheath degeneration appeared in 2 hours,extensive myelin sheath degeneration and mitochondrion degeneration and incisure and vacuoles in nucleus of neuron were found in 4 and 8 hours.Lipofuscin was found in cytoplasm of neuron 16 hour.Conclusion Oral ST exposure in mice could cause myelin sheath degeneration and damaged changes of neurons.
