Two Cases of Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome).
- Author:
Nak Joon CHO
;
Dal Yong CHOI
;
Sook Ja SON
;
Shil SHIN
- Publication Type:Original Article
- MeSH:
Adrenal Cortex Hormones;
Adult;
Capillaries;
Cicatrix;
Conjunctivitis;
Dermis;
Endothelial Cells;
Eosinophils;
Extremities;
Female;
Fever;
Humans;
Leukocytosis;
Neck;
Neutrophils;
Pharyngitis;
Recurrence;
Sweet Syndrome*;
Tongue;
Ulcer
- From:Korean Journal of Dermatology
1980;18(5):439-446
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute febrile neutrophilic dermatosis, which was introduced to the dermatologic literature by Sweet in 1964, is characterized by persistent high fever and preceding upper respiratory infection like symptoms, polymorphonuclear leukocytosis in the peripheral blood, raised painful plaques on the limbs, face and neck, histologically a dense dermal infiltration with polymorphonuclear leukocyte, dramatic response to corticosteroids, and the absence of scarring. Case 1 was a 35 year-old female who had suffered from malaise, sore throat, and fever 3 to 7 days before the each episode of the cutaneous manifestation. Painful, red, raised, well-demarcated plaques appeared on the face with tendency of recurrences, and was accompanied by a few, small, shallow ulcerations on the lower Iip and tongue, and conjunctivitis. Polymorphonuclear leukocytosis (10400 with 65%, 11600 with 75%) and elevated ESR(23mm/hr, 19mm/hr) were found on two occasions. Histologically a dense inflammatory cell infiltration composed predominantly of polymorphonuclear neutrophils, small round cells, and a few eosinophils were seen in the dermis and subcutis, especially around the dermal capillaries. Alao there were many nuclear debris and marked endothelial cell proliferations. (countinued...)
