Pharmacokinetics of cisplatin during pelvic isolated perfusion with the balloon occlusion technique in dogs
- VernacularTitle:应用介入技术行犬盆腔分离灌注中顺铂的药动学研究
- Author:
Yongcheng LIU
;
Feng WANG
;
Ailian LIU
;
Donghua JI
;
Lijun ZHAO
;
Ningfang WANG
- Publication Type:Journal Article
- Keywords:
Isolated perfusion;
Pelvic neoplasm;
Cisplatin;
Pharmacokinetics
- From:
Journal of Interventional Radiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To demonstrate the pharmacokinetic characters of cisplatin in isolated prefusion of dog pelvic.Methods Pelvic isolated perfusion with the balloon occlusion was performed in 11 dogs.Blood samples of perfusion and non-perfusion regions were assayed for platinum using atomic absorption spectrophotometer.Pharmacokinetic characters of cisplatin were analized. Results C_(pel max) 30.3 ?g/ml,and C_(sys max) 4.8 ?g/ml,and AUC_(pel 0～25min) 330 ?g/ml?min were observed in perfusion area.AUC_(sys 0～25min) in non-perfusion area was 56 ?g/ml?min. Conclusions Balloon catheter-mediated pelvic I-P has favorable pharmacokinetic characters for chemotherapeutics and therefore should be an alternative method to treat pelvic neoplasma.
