Experimental Study on Sedative, Hypnotic and Anticonvulsive Actions of Yi Xin Le Oral Liquid
- VernacularTitle:怡欣乐口服液镇静催眠及抗惊厥作用研究
- Author:
Shide SHI
;
Minwei ZHOU
;
Jianjun LI
;
Jianhong SHI
- Publication Type:Journal Article
- Keywords:
Yi Xin Le oral liquid;
Insomnia;
Mouse;
Sedation;
Hypnogenesis;
Anticonvulsion
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic mechanism of Chinese medicine of Yi Xin Le oral liquid (YXL) on insomnia. Methods Mice spontaneous activities,mice sleep time induced by sodium pentobarbital in the threshold dose and under the threshold dose and mice convulsion induced by strychnine nitrate were observed to evaluate the sedative, hypnotic and anticonvulsive actions of YXL. Results YXL could restrain the spontaneous movement in mice,had a synergistic action with sodium pentobarbital on mice sleep,and could counteract the convulsive attack induced by strychnine nitrate in a dose-dependent manner. Conclusion YXL has obvious sedative, hypnotic and anticonvulsive actions and this will supply evidence for its clinical usage.
