Anticoagulant Activities of Polysaccharides from the Heads of Rana temporaria chensinensis
- VernacularTitle:林蛙头多糖抗凝血活性的研究
- Author:
Liqin XU
;
Dejing SHANG
;
Qingwei LI
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Rana temporaria chensinensis;
Polysaccharides;
Anticoagulation
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anticoagulant effect of polysaccharides from the heads of Rana temporaria chensinensis(Chinese Forest Frogs). Methods In-vitro experiments were applied to test the effect of polysaccharides on recalcification time, prothrombin time, thrombase time , the activities of thrombin, hydrolyzing fibrin content, activated fibrin dissolve zymogen and blood clotting.. In the in-vivo experiment, bleeding time was measured by cutting mouse tail and clotting time was measured by glass sheet method. Results The polysaccharides from the heads of Chinese Forest Frogs had an obvious anticoagulant effect in a dose-effect manner, but had on thrombolytic action. It could prolong the bleeding time and the clotting time in vivo. Condusion The polysaccharides from the heads of Chinese Forest Frogs have the anticoagulatant activities in vitro and in vivo.
