Study on the Standardization of Similarity Evaluation Method of Chromatographic Fingerprints (Part Ⅱ)
- VernacularTitle:色谱指纹图谱相似度评价方法的规范化研究(二)
- Author:
Runtao TIAN
;
Peishan XIE
;
Yun YANG
- Publication Type:Journal Article
- Keywords:
Chromatographic fingerprints;
Similarity evaluation;
Standardization;
Multiple statistics;
Monte Carlo random simulation;
Bapleurum Chinense DC.
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the standardization of similarity evaluation method of chromatographic fingerprints. Methods HPLC and computer simulation method were used to analyze the content variation pattern of the characteristic compounds, the construction method of standard fingerprints and the statistical meanings of similarity evaluation respectively. Results The content distribution of characteristic compounds should obey normal probability. It is recommended that content information and median algorism should be used to generate reference fingerprints. The confidence factor of similarity coefficient also should be tested. Conclusion The process of compound sampling, establishment of criteria and result test are described and standardized from statistical aspect.
