The Effect to Expression of NF-?B, Caspase-3 and MMP-2 in Chronic Pelvic Inflammatory Rat by Rectal Ministration with the Penyankangshuan
- VernacularTitle:盆炎康栓对慢性盆腔炎模型大鼠子宫内膜细胞NF-?B、Caspase-3、MMP-2表达的影响
- Author:
Shaobin WEI
;
Yongqin YAO
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
Penyankangshuan;
chronic pelvic inflammation;
apoptosis;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-inflammatory mechanism of the Penyankangshuan (PYKS) in treating chronic pelvic inflammation. Methods After model rats with endometritis were established successflly, 6 groups were formed which were the high, the middle and the low dosage groups of the PYKS, the KFXYS (a kind of patent medicine has a similar effect) group, the model group, the normal group. The treated rats were continuously rectal administration 3 weeks, the expression of NF-?B, Caspase-3 and MMP-2 were observed in the high, the middle dosage groups of the PYKS, the KFXYS group, the model group and the normal group with immunohistochemistry. Results The PYKS obviously raised the expression of Caspase-3 and MMP-2, but decreased the expression of NF-?B. Conclusion The anti-inflammatory mechanism of the PYKS possibly raised the expression of Caspase-3 and MMP-2 of mice endometrial cells, decreased the expression of NF-?B, so as to reduce inflammation soakage in excess and formation of inflammatory medium, accelerate apoptosis and reduce local inflammation.
