Effects of Puerarin on Renal Advanced Glycosylation End Products and Expression of TGF-?_1 in Diabetic Rats
- VernacularTitle:葛根素对糖尿病大鼠肾脏糖基化终产物和转化生长因子-?_1表达的影响
- Author:
Changtian LI
;
Yanfei CHEN
- Publication Type:Journal Article
- Keywords:
puerarin;
diabetic nephropathy;
AGEs;
TGF-?1
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of puerarin on renal advanced glycosylation end products (AGEs), expression of transforming growth factor-?1 (TGF-?1) and pathomorphism in diabetic rats. Methods Rats were randomly divided into following groups:normal control rats (Group CN), diabetic rats (Group DM) and diabetic rats treated with puerarin (Group DP). After Puerarin was given to STZ-induced diabetic rats for 10 weeks, blood glucose, urine protein, glomerular basement membrance thickness (GBMT) and profile of kidney hypertrophy in diabetic rats were measured and analysed. The renal pathologic changes were observed by light microscopy and electron microscopy. Renal AGEs content was determined by expose time of fluorescence microscopy. The expression of TGF-?1 was examined by immunohistochemical methods. Results Urine protein, GBMT and profile of kidney hypertrophy were significantly increased in diabetic rats as compared with control animals (P
