Effect of Ligustrazini and Propofol on Hepatocellular Energy Metabolism in the Reperfusion Injury after Hepatic Ischemia in Rabbits
- VernacularTitle:川芎嗪联用异丙酚对实验性缺血-再灌注损伤肝脏能量代谢的干预
- Author:
Wantie WANG
;
Xiaoxiao QIU
;
Xuerong PAN
- Publication Type:Journal Article
- Keywords:
hepatic ischemia-reperfusion injury;
energe metablism;
ligustrazini;
propofol
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of ligustrazini (LGT) and propofol (PRO) on hepatocellular energy metabolism in the reperfusion injury after hepatic ischemia in rabbits and its mechanism. Methods The rabbits were randomly divided into four groups (n=10 in each), hepatic ischemia-reperfusion (HIR) group, HIR+LGT group (B), HIR+PRO group (C) and HIR+ LGT+PRO group (D). The contents of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), total adenylic acid number (TAN), energy charge (EC), malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide products (NO2-/NO3-) in the liver tissue were measured at 45 minutes after reperfusion. Results The contents of ATP, NO and SOD activity of the liver tissue in B, C, D groups were higher than those in HIR group (P
