Study on Optimum Emulsification Condition for Shizhenyu Cream with Orthogonal Design
- VernacularTitle:正交试验法优选湿疹愈乳膏基质成分的配比
- Author:
Xiaoling WANG
;
Lingtao LI
;
Hong MA
- Publication Type:Journal Article
- Keywords:
Shizhenyu Cream;
orthogonal design;
quality of emulsification;
formulation optimization
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To select an optimum emulsification condition for Shizhenyu Cream. Methods Formulation optimization of Shizhenyu Cream was performed based on the orthogonal experimental design. In this study, the stability and external appearance forms of the creams were taken as the index and the influence of factors such as ground substances, agitation time, velocity and temperature of the emulsification process was evaluated. Results The ideal emulsification condition of Shizhenyu Cream is: composite alcohol 30, silicon oil 15, glyceryl monostearate 5, peregal∶potassium dodecyl phosphonate 4∶10, 80 ℃, 4 000 r/min, 10 minutes, and adding the aqueous phase to the oil phase. Conclusion The ideal emulsification condition of Shizhenyu Cream was established with orthogonal design, and it has been proved to be stable, reasonable and scientific.
