Prescription design of Ophiopogon japonicus saponin enteric microsphere by spray drying technique
- VernacularTitle:喷雾干燥技术制备麦冬皂苷肠溶微球的处方设计研究
- Author:
Lan SHEN
;
Yi FENG
;
Desheng XU
;
Xiao LIN
- Publication Type:Journal Article
- Keywords:
Ophiopogon japonicus saponin enteric microsphere;
prescription design;
spray drying technique
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prescription factor on Ophiopogon japonicus saponin enteric microsphere by spray drying technique. Methods Observing the type and content of enteric coating material, the type of plasticizer, the type and dosage of antistickiness material by single factor. Optimizing the prescription by orthogonal test design. Results Both Eudragit Ⅱ and micronization silica gel made in China could meet the need of the preparation. The best prescription included the proportion between drug and enteric coating material (1∶4), the dosage of castor oil (1%), and the dosage of micronization silica gel (1.5%). Conclusion O. japonicus saponin enteric microsphere accorded with the expecting demand. The kind of medical subsidiary material made in China will be the main raw material in producing the enteric microsphere. The study of prescription design will provide the basis for realizing microencap-sulation in Chinese materia medica.
