The clinical significance of calcitonin gene related peptide(CGRP) level and gene sequence in congenital heart disease with pulmonary hypertension
- VernacularTitle:先天性心脏病肺动脉高压患儿血浆降钙素基因相关肽水平和基因测序的临床意义
- Author:
Zewei ZHANG
;
Jing YE
;
Jianhua LI
;
Lijun JIANG
;
Zhan GAO
- Publication Type:Journal Article
- Keywords:
Calcitonin gene related peptide;
Gene polymorphism;
Pulmonary hypertension;
Congenital heart disease
- From:
Chinese Journal of Emergency Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of CGRP level and gene sequence in congenital heart disease(CHD)with pulmonary hypertension.Methods The level of serum CGRP was tested by radioimmunoassy in 36 children with left to right shunt CHD,including 29 children with different severity of pulmonany hypertension(PH).Echo cardiography pulse wave Doppler tested the ratio of the pulmonary and systemic arterial pressure.The exon 5 in CGRP gene was directly sequenced in these patients. Results There were significant differences in serum levels of CGRP between the patients with mild PH and control group.The levels of serum CGRP were significantly decreased in patients with moderate or severe PH.There was significant negative line correlation between the levels of CGRP and pulmonary pressure.Base mutation were not found in the exon 5 in CGRP gene.Conclusion The CGRP might be involved in the pathophysiologic process of pulmonary hypertension in CHD.There is no gene expression polymorphism in encode sequence in CHD patients with pulmonary hypertension.
