Research on expression of CTGF in myocardial interstitial remodeling in infracted rat model
- VernacularTitle:结缔组织生长因子在大鼠心肌梗死后心肌间质重塑中表达的研究
- Author:
Yonglin GU
- Publication Type:Journal Article
- Keywords:
Connective tissue growth factor;
Myocardial infarction;
Myocardial interstitial remodeling
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Objective: To discuss the expression of CTGF in myocardial tissue during myocardial remodeling and to understand the molecular mechanism of myocardial remodeling after myocardial infarction.Methods: Twenty four SD rats were randomly divided into two groups sham group and infracted group.In infracted group left anterior descending coronary artery was ligated for 8 weeks but not in sham group.Collagen protein of myocardial tissue was tested with chemistry to understand myocardial interstitial remodeling.CTGF protein were studied with immunohistochemistry analysis.CTGF mRNA expression was tested by reverse transcription and polymerase chain reaction(RT-PCR).Results: Expressions of CTGF protein and mRNA were significantly enhanced(P
