Effect of HSP90 inhibins geldanamycin on invasion and metastasis of human breast cancer cell line
- VernacularTitle:HSP90的抑制剂Geldanamycin对乳腺癌细胞侵袭、转移能力的影响
- Author:
Hongxia LUO
- Publication Type:Journal Article
- Keywords:
Breast cancer cell;
Geldanamycin;
HSP90
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of HSP90 inhibitors Geldanamycin(GA) on invasion and motility potential in human breast cancer cell.Methods: The effects of HSP90 inhibitor GA on the adhesion?invasion and metastasis of human breast cancer line MDA-MB-231 and MDA-MB-435s in vitro were explored by MTT colorimetric and transwell chamber.Results: Treatd with GA,the adhesion? invasion and motility abilities of the MDA-MB-231 and MDA-MB-435s cells were decreased significantly as compared with the control guoup,(P
