Expression and clinical significance of Rb gene and MCM2 in prostate cancer
- VernacularTitle:Rb和MCM2蛋白在前列腺癌中的表达及临床意义
- Author:
Yunxiang LI
- Publication Type:Journal Article
- Keywords:
Prostate cancer;
Minichromosome maintenance protein 2(MCM2);
Retinoblastoma susceptibility gene(Rb)
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression of retinoblastoma susceptibility gene(Rb) and minichromosome maintenance protein 2(MCM2) in primary prostate cancer(PCa) and its clinical significance.Methods: The expression of MCM2 protein and pRb were detected in 49 cases of PCa,20 cases of benign prostate hyperplasia(BPH),10 cases of normal prostate tissues(NP) by EliVisionTM plus immunohistochemical staining.Results: The positive expression rate of pRb in PCa,BPH,NP were 44.90%,80% and 90% respectively.The expression level of pRb in PCa was significantly lower than that in BPH(P
