Study of in vitro antibacterial activity of faropenem against 194 clinical isolates
- VernacularTitle:法罗培南对临床分离194株致病菌的体外抗菌活性研究
- Author:
Chengwei LIU
- Publication Type:Journal Article
- Keywords:
Faropenem;
In vitro antibacterial activity
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study in vitro antibacterial activity of faropenem.Methods: The minimum inhibitory concentration(MIC) of faropenem,cefoperazone/sulbactam or cefotaxime against 194 clinical isolates was determined by agar dilution method.MIC50,MIC90 and the susceptible rate were counted.Results: MIC50 and MIC90 of faropenem were lower than or equal to 1?g/ml and 4?g/ml for all 194 clinical isolates respectively.All susceptible rates of faropenem were more than 90%.MIC90 of faropenem was similar to that of cefoperazone/sulbactam against beta-lactamase producing Escherichia coli and klebsierlla peumoniae,but was 1/32 MIC90 of cefotaxime.MIC90 of three antibiotics was similar against Proteus spp,Moraxella catarrhalis and Streptococcus pneumoniae.MIC90 of faropenem was marked lower than that of cefoperazone/sulbactam or cefotaxime against Staphylococcus aureus,Staphylococcus epidermidis and Enterococcus faecalis.Conclusion: Antibacterial activity of faropenem against clinical isolates is very strong and it is also strongly against beta-lactamase producing bacteria.It can be expected that faropenem will be used widely in clinic in china.
