Study of immune function in children with thalassanemia major after partial splenic embolization
- VernacularTitle:部分性脾栓塞术对地中海贫血患儿免疫功能的影响
- Author:
Quelin MEI
;
Yong CHEN
;
Pengcheng LIU
;
Yanhao LI
- Publication Type:Journal Article
- Keywords:
Thalassanemia major;
Humoral immunity/Cytoimmunity;
Embolization therapy
- From:
Journal of Interventional Radiology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of immunologic function in children with thalassanemia major after partial splenic embolization(PSE).Methods Immunoglobulins,T cell subsets were detected by immunologic turbidimetry and APAAP with monoclonal antibody respectively in 40 children with thalassanemia major and also in 20 healthy persons before and after PSE.These immunologic indexes were compared before and after PSE.Results The levels of IgG in serum were significantly lower one week after PSE than that before PSE.It turned to normal three weeks after PSE.The IgM,IgA levels remained unchanged during PSE.The levels of CD_3、CD_4、CD_4/CD_8 ratio in children with thalassanemia major were decreased(P
