Pharmacological Study on Antitussive and Antiasthmatic Actions of Nervilia fordii (Hance) Schitr.
- VernacularTitle:青天葵镇咳、平喘药理作用研究
- Author:
Qin DU
;
Murong YE
;
Zhenhua WANG
;
Honghua XU
- Publication Type:Journal Article
- Keywords:
NERVILIA FORDII (HANCE) SCHITR. /pharmacology;
ANTITUSSIVE;
ANTIASTHMA;
DISEASE MODELS, ANIMAL;
MICE;
GUINEA PIGS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the antitussive and antiasthmatic actions of Nervilia fordii (Hance) Schitr. (NF). [Methods] NIH mice were randomized into 8 groups: 3 NF water-extract groups and 3 NF ethanol-extract groups in high, moderate and low doses (19.2, 9.6 and 4.8 g?kg-1?d-1 respectively), positive control group (codeine phosphate 50 mg?kg-1?d-1 in the antitussive experiment and theocin 0.1g?kg-1?d-1 in the antiasthmatic experiment) and model group. Mice cough models induced by ultrasonic spray of ammonium hydroxide and guinea pigs asthma models induced by ultrasonic spray of histamine-acetylcholine mixture were adopted to observe the antitussive and antiasthmatic actions of NF. [Results] Water-extract and ethanol-extract of NF in three doses decreased the cough frequency in mice, and ethanol-extract of NF in three doses prolonged the cough latent period (P
