Therapeutic effects of nano-magnetoliposomes containing As_2O_3 combined with magnetic fluid hyperthermia on xenograft cervical carcinoma
- VernacularTitle:纳米As_2O_3磁性脂质体磁感应加热治疗裸鼠人宫颈癌移植瘤
- Author:
Dongsheng ZHANG
;
Qiusha TANG
;
Ziyu WANG
;
Xiangshan FAN
- Publication Type:Journal Article
- Keywords:
Xenograft cervical cancer;
Radiofrequency-induced hyperthermia;
Nano-magnetoliposomes with As_2O_3
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the inhibition effects and mechanics of nano-magnetoliposomes containing As_2O_3 (NMLA) combined with magnetic fluid hyperthermia on xenograft cervical carcinoma in nude mice. Methods After establishment of xenograft cervical carcinoma models in nude mice, nano-liposomes containing As_2O (NLA group), nano-magnetoliposomes (NML group) and NMLA (NMLA group) were injected into the xnograft cervical carcinoma, respectively, and all nude mice were exposed to AMF for three times. The inhibitive ratios (IR) of the tumors, apoptosis index (AI), proliferation index (PI) and the expression of Bcl-2 and Bax proteins were measured, as well as the function of liver and kidney. Results IRs in NLA, NML and NMLA groups were 57.06% (P0.05). The obvious necrosis was observed in the tumor tissues in NLA, NML and NMLA groups, but not in the peripheral tissues of the tumors and the visceras. Conclusion NMLA, without toxicity of liver and kidney, might be a desirable composite carrier of targeted treatment with chemotherapy and thermotherapy simultaneously.
