Effects of Modafinil on Vestibular Function during 24 h Sleep Deprivation.
- VernacularTitle:服用莫达非尼对24h睡眠剥夺条件下人前庭功能的影响
- Author:
Hao ZHAN
;
Sujiang XIE
;
Hongbo JIA
;
Sihuang WEI
;
Baisheng JING
;
Tong LI
- Publication Type:Journal Article
- Keywords:
sleep deprivation;
central nervous system agents;
wake-promoting agents;
modafinil;
vestibular function
- From:Space Medicine & Medical Engineering
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of modafinil,a new wake-promoting agent, on vestibular function during 24 h sleep deprivation(SD). Method Eight male healthy young volunteers were exposed to two 24 h periods of continuous wakefulness during the crossover experiment. In one period, 200 mg doses of modafinil were given and in the other, separated by one week, matching placebos were administered. The SD time started from 8:00 of the first day to 8:00 of the second day. Drugs was given at 0:00 of the second day. Vestibular function was tested at 21:00 of the first day and 1 ,3,5,7 h after drug administration. Result The accuracy of saccade tracking and the gains of VVOR(visual-vestibular optokinetic reflex)and OKN(optokinetic nystagmus)in the placebo group decreased during 24 h SD, especially at 1: 00～5:00 of the second day, while OKN gains in the modafinil group was increased significantly. There were no significant differences of other vestibular function between modafinil group and placebo group. Conclusion Twenty four SD can influence vestibular function in certain degree,but optokinetic nystagmus can be improved by modafinil.
