Influences of Chinese Herbal Medicine Compound on Insulin and Frame Muscle Glucose Transport 4 Gene Expression of Type 2 Diabet in Rat
- VernacularTitle:糖脉平胶囊对2型糖尿病大鼠胰岛素及骨骼肌葡萄糖转运体4基因表达的影响
- Author:
Dongchu HE
;
Jinjun XU
;
Xiaohong WANG
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicine;
type 2 diabet;
insulin resistance;
GluT4 gene;
hyvirdism in situ
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of Chinese herbal medicine compound Tang Mai Ping (TMP) capsule to type 2 diabet in rats. Methods The models of type 2 diabetic rats were established by injecting lower dosage of streptozotocin (STZ, 35 mg/kg) to belly, and fed high sucrose and high fat diet. Modle rats were randomly divided into model group, TMP group, and Erjiashuanggu (EJS) group, at the same time normal control. The content of plasma insulin was detected by radio-immunicy, mRNA expressing of frame muscle of Glucose Transporter 4 (GluT4) gene was detected with hyvirdism in situ. Results After built model, levels of insulin were obviously ascended in rats, but the expression of GluT4 mRNA lower significantly (P
