The Effects of Xiefuzhuyu Decoction on Myocardial Cellar Apoptosis and Expression of ICAM-1 Gene Protein in Rats of Experimental Acute Ischemic Myocardium Induced by Coronary Artery Occlusion
- VernacularTitle:血府逐瘀汤对结扎冠脉所致缺血大鼠心肌细胞凋亡及ICAM-1蛋白表达的影响
- Author:
Qiuyan ZHANG
;
Jianfeng SU
;
Bingxiang DENG
- Publication Type:Journal Article
- Keywords:
Xiefuzhuyu decoction;
acute myocardial ischemia;
myocardial cellar apoptosis;
ICAM-1
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Xiefuzhuyu decoction on myocardial cellar apoptosis and expression of ICAM-1 gene protein in rats of experimental acute ischemic myocardium. Methods The left anterior descending coronary artery was ligated to make a model of acute ischemic myocardium. The changes in myocardial cellar apoptosis and the ICAM-1 gene expression were detected. Results The number of myocardium cellar apoptosis in Xiefuzhuyu group and Diaoxinxiekang group were significantly less than those of ischemic model group respectively. The number of myocyte necrotic cell increased in ischemic group. At the same time, the expression of ICAM-1 supported this condition. Conclusion Xiefuzhuyu decoction and Diaoxinxiekang can protect ischemic myocardium.
