Clinicopathological features of anorectal malignant melanoma
- VernacularTitle:肛管直肠恶性黑色素瘤13例病理分析
- Author:
Di WANG
;
Xiangshi LU
- Publication Type:Journal Article
- Keywords:
Melanoma;
Anal canal;
Rectum
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathological characteristies,differential diagnosis,etiological factor and treatment of anorectal malignant melanoma(AMM). Methods Clinical pathological characteristics and immunohistochemical findings were observed in 13 cases of anorectal malignant melanoma,with review of related literature.Results Average age was 55.8 years. And often occurred in the middle and old. Under microscope, the tumor was complicated constructionally, and the tumor cells were variform. Usually in tightly packed nests, dispersed sheet and trabecular, melanin pigment could be observed in the majority of AMM, but sometimes ameLanotic pigment was present. Immunohistochemiscal the tumor cells were positive for HMB 45, S-100 and vimetin. Conclnsion AMM is a high malignant tumor with very poor prognosis. So,it should be diagnosed and treated early. HMB 45 and S-100 are sensitive tumor markers for AMM.
