GENE EXPRESSION OF KIFs IN CORTEX OF RATS INJECTED WITH ?-AMYLOID INTO BRAIN VENTRICLE
- VernacularTitle:脑室内注射?淀粉样蛋白造成大鼠大脑皮层KIF家族基因表达变化
- Author:
Xin XU
- Publication Type:Journal Article
- Keywords:
Kinesin superfamily;
Amyloid;
Gene expression;
Real-time RT-PCR;
Rat
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of amyloid on the expression of kinesin superfamily(KIFs) genes in cortex of Wistar rats. Methods The animal model of Alzheimer's disease was prepared by injection of amyloid into brain ventricle of rats.The learning impairments were verified by water maze test.The levels of mRNA for six kinesin superfamily genes,kinesin,KIFlb,KIFlc,KIF3a,KIF3c,and KIF4,in cortex of rats,were estimated by real-time RT-PCR. Results Two weeks after amyloid injection,the rats showed significant learning impairments.In cortex,the expression of KIF genes was increased after amyloid injection.Conclusion\ The increase of KIF gene may be an evidence for the excitotoxity of amyloid to neurons.
