Effect of Supercritical Fluid Carbon Dioxide Extracts from Pericarpium Zanthoxyli on in- Vitro Activity of Guinea Pig Trachea
- VernacularTitle:花椒超临界萃取物对豚鼠离体气管活动的影响
- Author:
Yuxiang ZHANG
;
Xiaohui ZENG
;
Ruiling ZHOU
;
Yuxing CHENG
;
Jingchao CUI
- Publication Type:Journal Article
- Keywords:
Pericarpium Zanthoxyli;
Supercritical fluid extraction;
Guinea pigs;
Trachea in vitro;
Therapeutic mechanism
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Pericarpium Zanthoxyli (HJ) on guinea pigs trachea in vitro and its therapeutic mechanism. Methods The actions of HJ on the contraction of normal trachea and on the spasm of spasmodic tracheas caused by acetylcholine (Ach) and histamine phosphate (HIS), as well as the actions on intracellular Ca2+ - dependent contraction and extracellular Ca2+ - dependent contraction induced by HIS were observed. Results HJ could inhibit the guinea pigs trachea contraction , antagonize the contraction of trachea spasm induced by Ach and HIS , restrain the extracellular Ca2+ - dependent contraction induced by HIS in a dose- dependent manner. Conclusion HJ has an antiasthma effect.
