Influence of Kidney- yang Warming Therapy on Expression of Th_1/Th_2 Cytokines in Rats with Allergic Rhinitis
- VernacularTitle:温肾补阳法对肾阳虚变应性鼻炎大鼠模型血清Th_1/Th_2细胞因子表达的影响
- Author:
Yan RUAN
;
Zhanjun YANG
;
Wei CHEN
;
Sun LI
;
Yanlei FENG
- Publication Type:Journal Article
- Keywords:
Kidney- yang Warming therapy;
Jinkui Shenqi Pill;
Allergic rhinitis (AR);
IL- 2;
IL- 4;
IL- 5;
IFN- ?
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the relationship between kidney- yang- deficiency syndrome and the Th1/Th2 expression, and to investigate the effect of kidney- yang warming therap yon the Th1/Th2 expression. Methods Kidney- yang- deficiency rat models were firstly induced by adenine and then were sensitizated by inhalation of ovalbumin to establish allergic rhinitis (AR)models .The treatment group was given Jinkui Shenqi pill. After treatment , the changes of behavior , secretion of nasal cavity and nasal mucosa were observed. The levels of Th1 cytokines IFN- ? , IL- 2 and Th2 cytokines IL- 4 , IL- 5 in serum were determined by ELISA. Results The behavioral score in AR group and kidney- yang- deficiency AR group was higher than that in the treatment group and normal control group ( P
