Experimental Study of Tiaozhi Baogan Capsule in Preventing and Treating Fatty Liver in Rats
- VernacularTitle:调脂保肝胶囊防治大鼠脂肪肝的实验研究
- Author:
Lijuan YANG
;
Xianli MENG
;
Zhang WANG
;
Yuxia XIONG
- Publication Type:Journal Article
- Keywords:
Tiaozhi Baogan Capsule (TBC);
Fatty Liver;
High fat Diet;
Liver index;
Pathological examination;
Blood biochemistry
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive and therapeutic effects of Tiaozhi Baogan Capsule (TBC) on fatty liver in rats and to explore its therapeutic mechanism. Methods SD rat models of fatty liver were set up by feeding high fat diet. After the treatment of TBC, the general physical state, liver index (the ratio of liver weight with body weight) , hepatic pathological changes , blood biochemical indices were observed in model rats. Results TBC could obviously ameliorate liver pathological changes in model rats, relieve hepatic steatosis and hepatocellular necrosis, decrease the content of malondialdehyde( MDA) and increase the vitality of superoxide dismustase (SOD) in serum and liver, lower the content of total cholesterol (TC) and low- density lipoprotein (LDL) in serum and decreae the liver index (P
