Study on the Standardization of Similarity Evaluation Method of Chromatographic Fingerprints (PartⅠ )
- VernacularTitle:色谱指纹图谱相似度评价方法的规范化研究(一)
- Author:
Runtao TIAN
;
Peishan XIE
- Publication Type:Journal Article
- Keywords:
Chromatographic fingerprints;
Similarity evaluation;
Standardization;
Multivariate data analysis;
Monte Carlo random simulation
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the standardization of similarity evaluation method of chromatographic fingerprints. Methods Computer simulation and HPLC method were used to investigate the characteristics of different similarity evaluation methods and the criteria of characteristic variables selection in chromatographic fingerprints. Results Cosine ratio and correlation coefficient should be the first choice for similarity calculation based on chromatographic peak area. Peak area is recommend to be used as the characteristic variable for chromatographic fingerprints. Conclusion The features of the commonly used chromatographic fingerprint evaluation methods are described and their range of application are defined.
